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### Running command:
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###   /Library/Frameworks/R.framework/Resources/bin/R CMD check --install=check:VariantAnnotation.install-out.txt --library=/Library/Frameworks/R.framework/Resources/library --no-vignettes --timings VariantAnnotation_1.52.0.tar.gz
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* using log directory ‘/Users/biocbuild/bbs-3.20-bioc/meat/VariantAnnotation.Rcheck’
* using R version 4.4.2 (2024-10-31)
* using platform: x86_64-apple-darwin20
* R was compiled by
    Apple clang version 14.0.0 (clang-1400.0.29.202)
    GNU Fortran (GCC) 12.2.0
* running under: macOS Monterey 12.7.6
* using session charset: UTF-8
* using option ‘--no-vignettes’
* checking for file ‘VariantAnnotation/DESCRIPTION’ ... OK
* checking extension type ... Package
* this is package ‘VariantAnnotation’ version ‘1.52.0’
* checking package namespace information ... OK
* checking package dependencies ... NOTE
Depends: includes the non-default packages:
  'BiocGenerics', 'MatrixGenerics', 'GenomeInfoDb', 'GenomicRanges',
  'SummarizedExperiment', 'Rsamtools'
Adding so many packages to the search path is excessive and importing
selectively is preferable.
* checking if this is a source package ... OK
* checking if there is a namespace ... OK
* checking for hidden files and directories ... OK
* checking for portable file names ... OK
* checking for sufficient/correct file permissions ... OK
* checking whether package ‘VariantAnnotation’ can be installed ... OK
* used C compiler: ‘Apple clang version 14.0.0 (clang-1400.0.29.202)’
* used SDK: ‘MacOSX11.3.sdk’
* checking installed package size ... NOTE
  installed size is  5.8Mb
  sub-directories of 1Mb or more:
    R         3.0Mb
    extdata   1.2Mb
    libs      1.1Mb
* checking package directory ... OK
* checking ‘build’ directory ... OK
* checking DESCRIPTION meta-information ... OK
* checking top-level files ... OK
* checking for left-over files ... OK
* checking index information ... OK
* checking package subdirectories ... OK
* checking code files for non-ASCII characters ... OK
* checking R files for syntax errors ... OK
* checking whether the package can be loaded ... OK
* checking whether the package can be loaded with stated dependencies ... OK
* checking whether the package can be unloaded cleanly ... OK
* checking whether the namespace can be loaded with stated dependencies ... OK
* checking whether the namespace can be unloaded cleanly ... OK
* checking dependencies in R code ... WARNING
'::' or ':::' import not declared from: ‘curl’
Unexported objects imported by ':::' calls:
  ‘BiocGenerics:::replaceSlots’ ‘BiocGenerics:::testPackage’
  ‘S4Vectors:::expandByColumnSet’ ‘S4Vectors:::labeledLine’
  ‘S4Vectors:::recycleVector’ ‘S4Vectors:::selectSome’
  ‘SummarizedExperiment:::.SummarizedExperiment.charbound’
  ‘SummarizedExperiment:::.cbind.DataFrame’
  ‘rtracklayer:::checkArgFormat’
  See the note in ?`:::` about the use of this operator.
* checking S3 generic/method consistency ... OK
* checking replacement functions ... OK
* checking foreign function calls ... OK
* checking R code for possible problems ... NOTE
VRangesForMatching: no visible binding for global variable ‘REF’
VRangesForMatching: no visible binding for global variable ‘ALT’
Undefined global functions or variables:
  ALT REF
* checking Rd files ... WARNING
checkRd: (5) PROVEANDb-class.Rd:24-27: \item in \describe must have non-empty label
checkRd: (5) PROVEANDb-class.Rd:28-32: \item in \describe must have non-empty label
checkRd: (5) PROVEANDb-class.Rd:33-37: \item in \describe must have non-empty label
checkRd: (5) PROVEANDb-class.Rd:38-42: \item in \describe must have non-empty label
checkRd: (5) PROVEANDb-class.Rd:43-49: \item in \describe must have non-empty label
checkRd: (5) PolyPhenDb-class.Rd:25-28: \item in \describe must have non-empty label
checkRd: (5) PolyPhenDb-class.Rd:29-33: \item in \describe must have non-empty label
checkRd: (5) PolyPhenDb-class.Rd:34-38: \item in \describe must have non-empty label
checkRd: (5) PolyPhenDb-class.Rd:39-45: \item in \describe must have non-empty label
checkRd: (5) PolyPhenDb-class.Rd:46-52: \item in \describe must have non-empty label
checkRd: (5) SIFTDb-class.Rd:24-27: \item in \describe must have non-empty label
checkRd: (5) SIFTDb-class.Rd:28-32: \item in \describe must have non-empty label
checkRd: (5) SIFTDb-class.Rd:33-37: \item in \describe must have non-empty label
checkRd: (5) SIFTDb-class.Rd:38-44: \item in \describe must have non-empty label
checkRd: (5) VCF-class.Rd:107-109: \item in \describe must have non-empty label
checkRd: (5) VCF-class.Rd:110-121: \item in \describe must have non-empty label
checkRd: (5) VCF-class.Rd:129-170: \item in \describe must have non-empty label
checkRd: (5) VCF-class.Rd:171-177: \item in \describe must have non-empty label
checkRd: (5) VCF-class.Rd:178-183: \item in \describe must have non-empty label
checkRd: (5) VCF-class.Rd:184-188: \item in \describe must have non-empty label
checkRd: (5) VCF-class.Rd:189-197: \item in \describe must have non-empty label
checkRd: (5) VCF-class.Rd:198-204: \item in \describe must have non-empty label
checkRd: (5) VCF-class.Rd:205-211: \item in \describe must have non-empty label
checkRd: (5) VCF-class.Rd:212-216: \item in \describe must have non-empty label
checkRd: (5) VCF-class.Rd:217-221: \item in \describe must have non-empty label
checkRd: (5) VCF-class.Rd:222-226: \item in \describe must have non-empty label
checkRd: (5) VCF-class.Rd:227-240: \item in \describe must have non-empty label
checkRd: (5) VCF-class.Rd:241-246: \item in \describe must have non-empty label
checkRd: (5) VCF-class.Rd:254-258: \item in \describe must have non-empty label
checkRd: (5) VCF-class.Rd:259-266: \item in \describe must have non-empty label
checkRd: (5) VCF-class.Rd:267-284: \item in \describe must have non-empty label
checkRd: (5) VCF-class.Rd:291-304: \item in \describe must have non-empty label
checkRd: (5) VCFHeader-class.Rd:47-51: \item in \describe must have non-empty label
checkRd: (5) VCFHeader-class.Rd:58-61: \item in \describe must have non-empty label
checkRd: (5) VCFHeader-class.Rd:62-66: \item in \describe must have non-empty label
checkRd: (5) VCFHeader-class.Rd:67-86: \item in \describe must have non-empty label
checkRd: (5) VCFHeader-class.Rd:87-94: \item in \describe must have non-empty label
checkRd: (5) VCFHeader-class.Rd:95-100: \item in \describe must have non-empty label
checkRd: (5) VCFHeader-class.Rd:101-106: \item in \describe must have non-empty label
checkRd: (5) VCFHeader-class.Rd:107-111: \item in \describe must have non-empty label
checkRd: (5) VCFHeader-class.Rd:112-118: \item in \describe must have non-empty label
checkRd: (5) VRanges-class.Rd:146-178: \item in \describe must have non-empty label
checkRd: (5) VRanges-class.Rd:179-224: \item in \describe must have non-empty label
checkRd: (5) VRanges-class.Rd:232-265: \item in \describe must have non-empty label
checkRd: (5) VRanges-class.Rd:266-268: \item in \describe must have non-empty label
checkRd: (5) VRanges-class.Rd:269-281: \item in \describe must have non-empty label
checkRd: (5) VRanges-class.Rd:290-292: \item in \describe must have non-empty label
checkRd: (5) VRanges-class.Rd:293-295: \item in \describe must have non-empty label
checkRd: (5) VRanges-class.Rd:296-299: \item in \describe must have non-empty label
checkRd: (5) VRanges-class.Rd:300-303: \item in \describe must have non-empty label
checkRd: (5) VRanges-class.Rd:304-307: \item in \describe must have non-empty label
checkRd: (5) VRanges-class.Rd:308-310: \item in \describe must have non-empty label
checkRd: (5) VRanges-class.Rd:311-314: \item in \describe must have non-empty label
checkRd: (5) VRanges-class.Rd:315-319: \item in \describe must have non-empty label
checkRd: (5) VRanges-class.Rd:320-322: \item in \describe must have non-empty label
checkRd: (5) VRanges-class.Rd:323-326: \item in \describe must have non-empty label
checkRd: (5) VRanges-class.Rd:327-330: \item in \describe must have non-empty label
checkRd: (5) VRanges-class.Rd:336-339: \item in \describe must have non-empty label
checkRd: (5) VRanges-class.Rd:340-344: \item in \describe must have non-empty label
checkRd: (5) VRanges-class.Rd:345-349: \item in \describe must have non-empty label
checkRd: (5) VRanges-class.Rd:355-358: \item in \describe must have non-empty label
checkRd: (5) VRanges-class.Rd:359-372: \item in \describe must have non-empty label
checkRd: (5) VRangesList-class.Rd:35-38: \item in \describe must have non-empty label
checkRd: (5) VRangesList-class.Rd:44-47: \item in \describe must have non-empty label
checkRd: (5) VRangesList-class.Rd:48-52: \item in \describe must have non-empty label
checkRd: (5) VRangesList-class.Rd:58-62: \item in \describe must have non-empty label
checkRd: (5) VariantType-class.Rd:134-138: \item in \describe must have non-empty label
checkRd: (5) VariantType-class.Rd:139-143: \item in \describe must have non-empty label
checkRd: (5) VariantType-class.Rd:144-149: \item in \describe must have non-empty label
checkRd: (5) VariantType-class.Rd:150-154: \item in \describe must have non-empty label
checkRd: (5) VariantType-class.Rd:155-159: \item in \describe must have non-empty label
checkRd: (5) VcfFile-class.Rd:31-34: \item in \describe must have non-empty label
checkRd: (5) VcfFile-class.Rd:35-37: \item in \describe must have non-empty label
checkRd: (5) VcfFile-class.Rd:42-43: \item in \describe must have non-empty label
checkRd: (5) VcfFile-class.Rd:44-45: \item in \describe must have non-empty label
checkRd: (5) VcfFile-class.Rd:46-47: \item in \describe must have non-empty label
checkRd: (5) VcfFile-class.Rd:48-49: \item in \describe must have non-empty label
checkRd: (5) VcfFile-class.Rd:50-51: \item in \describe must have non-empty label
checkRd: (5) VcfFile-class.Rd:52-54: \item in \describe must have non-empty label
checkRd: (5) VcfFile-class.Rd:59-60: \item in \describe must have non-empty label
checkRd: (5) VcfFile-class.Rd:61-62: \item in \describe must have non-empty label
checkRd: (5) VcfFile-class.Rd:67-69: \item in \describe must have non-empty label
checkRd: (-1) VcfFile-class.Rd:75: Lost braces in \itemize; meant \describe ?
checkRd: (-1) VcfFile-class.Rd:77-78: Lost braces in \itemize; meant \describe ?
checkRd: (-1) VcfFile-class.Rd:80: Lost braces in \itemize; meant \describe ?
checkRd: (-1) VcfFile-class.Rd:82-83: Lost braces in \itemize; meant \describe ?
checkRd: (-1) VcfFile-class.Rd:85-87: Lost braces in \itemize; meant \describe ?
checkRd: (-1) VcfFile-class.Rd:89: Lost braces in \itemize; meant \describe ?
checkRd: (-1) isSNV-methods.Rd:100-102: Lost braces in \itemize; meant \describe ?
checkRd: (-1) isSNV-methods.Rd:103-107: Lost braces in \itemize; meant \describe ?
checkRd: (-1) isSNV-methods.Rd:108-112: Lost braces in \itemize; meant \describe ?
checkRd: (-1) isSNV-methods.Rd:113-116: Lost braces in \itemize; meant \describe ?
checkRd: (-1) isSNV-methods.Rd:117-120: Lost braces in \itemize; meant \describe ?
checkRd: (-1) isSNV-methods.Rd:121-124: Lost braces in \itemize; meant \describe ?
checkRd: (-1) isSNV-methods.Rd:125-129: Lost braces in \itemize; meant \describe ?
checkRd: (-1) readVcf-methods.Rd:64-69: Lost braces in \itemize; meant \describe ?
checkRd: (-1) readVcf-methods.Rd:70-78: Lost braces in \itemize; meant \describe ?
checkRd: (-1) summarizeVariants-methods.Rd:75-95: Lost braces in \itemize; meant \describe ?
checkRd: (-1) summarizeVariants-methods.Rd:97-103: Lost braces in \itemize; meant \describe ?
* checking Rd metadata ... OK
* checking Rd cross-references ... OK
* checking for missing documentation entries ... OK
* checking for code/documentation mismatches ... OK
* checking Rd \usage sections ... OK
* checking Rd contents ... OK
* checking for unstated dependencies in examples ... OK
* checking line endings in C/C++/Fortran sources/headers ... OK
* checking line endings in Makefiles ... OK
* checking compilation flags in Makevars ... OK
* checking for GNU extensions in Makefiles ... NOTE
GNU make is a SystemRequirements.
* checking for portable use of $(BLAS_LIBS) and $(LAPACK_LIBS) ... OK
* checking use of PKG_*FLAGS in Makefiles ... OK
* checking compiled code ... NOTE
Note: information on .o files is not available
File ‘/Library/Frameworks/R.framework/Versions/4.4-x86_64/Resources/library/VariantAnnotation/libs/VariantAnnotation.so’:
  Found ‘___assert_rtn’, possibly from ‘assert’ (C)
  Found ‘___stderrp’, possibly from ‘stderr’ (C)
  Found ‘___stdoutp’, possibly from ‘stdout’ (C)
  Found ‘_abort’, possibly from ‘abort’ (C)
  Found ‘_exit’, possibly from ‘exit’ (C)
File ‘VariantAnnotation/libs/VariantAnnotation.so’:
  Found non-API calls to R: ‘R_GetConnection’, ‘R_WriteConnection’

Compiled code should not call entry points which might terminate R nor
write to stdout/stderr instead of to the console, nor use Fortran I/O
nor system RNGs nor [v]sprintf. The detected symbols are linked into
the code but might come from libraries and not actually be called.
Compiled code should not call non-API entry points in R.

See ‘Writing portable packages’ in the ‘Writing R Extensions’ manual.
* checking files in ‘vignettes’ ... OK
* checking examples ... OK
Examples with CPU (user + system) or elapsed time > 5s
                            user system elapsed
locateVariants-methods    40.074  1.139  42.015
predictCoding-methods     31.016  0.783  32.254
summarizeVariants-methods 12.125  0.196  12.535
PROVEANDb-class            7.617  3.641  17.042
readVcf-methods            7.741  0.124   8.100
filterVcf-methods          5.338  0.254   6.795
post_Hs_region             0.080  0.007   7.425
* checking for unstated dependencies in ‘tests’ ... OK
* checking tests ...
  Running ‘VariantAnnotation_unit_tests.R’
 OK
* checking for unstated dependencies in vignettes ... OK
* checking package vignettes ... OK
* checking running R code from vignettes ... SKIPPED
* checking re-building of vignette outputs ... SKIPPED
* checking PDF version of manual ... OK
* DONE

Status: 2 WARNINGs, 5 NOTEs
See
  ‘/Users/biocbuild/bbs-3.20-bioc/meat/VariantAnnotation.Rcheck/00check.log’
for details.