IsoGeneGUI

A graphical user interface to conduct a dose-response analysis of microarray data

Bioconductor version: Development (2.8)

The IsoGene Graphical User Interface (IsoGene-GUI) is a user friendly interface of the IsoGene package which is aimed to identify for genes with a monotonic trend in the expression levels with respect to the increasing doses using several test statistics: global likelihood ratio test (E2), Bartholomew 1961, Barlow et al. 1972 and Robertson et al. 1988), Williams (1971, 1972), Marcus (1976), the M (Hu et al. 2005) and the modified M (Lin et al. 2007). The p-values of the global likelihood ratio test (E2) are obtained using the excat distribution and permutation. The other four test statistics are obtained using permutation . Several p-values adjustment are provided: Bonferroni, Holm (1979), Hochberg (1988), and Sidak procedures for controlling the family-wise Type I error rate (FWER), and BH (Benjamini and Hochberg 1995) and BY (Benjamini and Yekutieli 2001) procedures are used for controlling the FDR. the inference is based on resampling methods, which control the False Discovery Rate (FDR) (both permutations (Ge et al., 2003) and the Significance Analysis of Microarrays (SAM), Tusher et al., 2001).

Author: Setia Pramana, Dan Lin, Philippe Haldermans, Tobias Verbeke

Maintainer: Setia Pramana

To install this package, start R and enter:

source("http:///biocLite.R")
biocLite("IsoGeneGUI")    

Documentation

PDF

R Script

IsoGeneGUI Vignette

Reference Manual

Details

biocViews	Microarray, Statistics, DifferentialExpression, GUI
Depends	tcltk, tkrplot, IsoGene
Imports	multtest, relimp, WriteXLS, gdata, RColorBrewer, geneplotter
Suggests	RUnit
System Requirements
License	GPL-2
URL	http://www.ibiostat.be/software/IsoGeneGUI/index.html
Depends On Me
Imports Me
Suggests Me
Version	1.3.1

Package Downloads

Package Source	IsoGeneGUI_1.3.1.tar.gz
Windows Binary	IsoGeneGUI_1.3.1.zip (32- & 64-bit)
MacOS 10.5 (Leopard) binary	IsoGeneGUI_1.3.1.tgz
Package Downloads Report	Download Stats