SPIA

Signaling Pathway Impact Analysis (SPIA) using combined evidence of pathway over-representation and unusual signaling perturbations

Bioconductor version: Development (2.8)

This package implements the Signaling Pathway Impact Analysis (SPIA) which uses the information form a list of differentially expressed genes and their log fold changes together with signaling pathways topology, in order to identify the pathways most relevant to the condition under the study.

Author: Adi Laurentiu Tarca, Purvesh Kathri and Sorin Draghici

Maintainer: Adi Laurentiu Tarca

To install this package, start R and enter:

source("http:///biocLite.R")
biocLite("SPIA")    

Documentation

PDF

R Script

SPIA

Reference Manual

Details

biocViews	Microarray, GraphsAndNetworks
Depends	R, graphics
Imports	graphics
Suggests	graph, Rgraphviz, KEGGgraph, hgu133plus2.db
System Requirements
License	GPL (>= 2)
URL	http://bioinformatics.oxfordjournals.org/cgi/reprint/btn577v1
Depends On Me
Imports Me
Suggests Me	KEGGgraph
Version	2.0.0

Package Downloads

Package Source	SPIA_2.0.0.tar.gz
Windows Binary	SPIA_2.0.0.zip (32- & 64-bit)
MacOS 10.5 (Leopard) binary	SPIA_2.0.0.tgz
Package Downloads Report	Download Stats