New Packages: Bioconductor

http://bioconductor.org/packages/devel/bioc/html/sbgr.html sbgr R Client for Seven Bridges Genomics API

2015-08-23T02:38:05.641033Z

R client for Seven Bridges Genomics API.
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http://bioconductor.org/packages/devel/bioc/html/GEOsearch.html GEOsearch GEOsearch

Zhicheng Ji, Hongkai Ji — 2015-08-21T15:17:31.980789Z

GEOsearch is an extendable search engine for NCBI GEO (Gene Expression Omnibus). Instead of directly searching the term, GEOsearch can find all the gene names contained in the search term and search all the alias of the gene names simultaneously in GEO database. GEOsearch also provides other functions such as summarizing common biology keywords in the search results.
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http://bioconductor.org/packages/devel/bioc/html/ldblock.html ldblock data structures for linkage disequilibrium measures in populations

2015-08-15T13:47:38.858687Z

Define data structures for linkage disequilibrium measures in populations.
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http://bioconductor.org/packages/devel/bioc/html/Path2PPI.html Path2PPI Prediction of pathway-specific protein-protein interaction networks

Oliver Philipp [aut, cre], Ina Koch [ctb] — 2015-08-14T22:32:40.567773Z

Package to predict pathway specific protein-protein interaction (PPI) networks in target organisms for which only a view information about PPIs is available. Path2PPI uses PPIs of the pathway of interest from other well established model organisms to predict a certain pathway in the target organism. Path2PPI only depends on the sequence similarity of the involved proteins.
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http://bioconductor.org/packages/devel/bioc/html/myvariant.html myvariant Accesses MyVariant.info variant query and annotation services

Adam Mark — 2015-08-13T21:21:16.953340Z

MyVariant.info is a comprehensive aggregation of variant annotation resources. myvariant is a wrapper for querying MyVariant.info services
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http://bioconductor.org/packages/devel/bioc/html/ChIPComp.html ChIPComp Quantitative comparison of multiple ChIP-seq datasets

Hao Wu, Li Chen, Zhaohui S.Qin, Chi Wang — 2015-08-18T05:25:13.351279Z

ChIPComp detects differentially bound sharp binding sites across multiple conditions considering matching control.
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http://bioconductor.org/packages/devel/bioc/html/BBCAnalyzer.html BBCAnalyzer BBCAnalyzer: an R/Bioconductor package for visualizing base counts

Sarah Sandmann — 2015-08-13T21:21:16.953340Z

BBCAnalyzer is a package for visualizing the relative or absolute number of bases, deletions and insertions at defined positions in sequence alignment data available as bam files in comparison to the reference bases. Markers for the relative base frequencies, the mean quality of the detected bases, known mutations or polymorphisms and variants called in the data may additionally be included in the plots.
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http://bioconductor.org/packages/devel/bioc/html/TCGAbiolinks.html TCGAbiolinks TCGAbiolinks: An R/Bioconductor package for integrative analysis with TCGA data

2015-08-24T21:21:11.732076Z

The aim of TCGAbiolinks is : i) facilitate the TCGA open-acess data retrieval, ii) prepare the data using the appropriate pre-processing strategies, iii) provide the means to carry out different standard analyses and iv) allow the user to download a specific version of the data and thus to easily reproduce earlier research results. In more detail, the package provides multiple methods for analysis (e.g., differential expression analysis, identifying differentially methylated regions) and methods for visualization (e.g., survival plots, volcano plots, starburst plots) in order to easily develop complete analysis pipelines.
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http://bioconductor.org/packages/devel/bioc/html/ABAEnrichment.html ABAEnrichment Gene expression enrichment in human brain regions

Steffi Grote — 2015-08-26T13:32:02.378827Z

The package ABAEnrichment is designed to test for enrichment of user defined candidate genes in the set of expressed genes in different human brain regions. The core function 'aba_enrich' integrates the expression of the candidate gene set (averaged across donors) and the structural information of the brain using an ontology, both provided by the Allen Brain Atlas project. 'aba_enrich' interfaces the ontology enrichment software FUNC to perform the statistical analyses. Additional functions provided in this package like 'get_expression' and 'plot_expression' facilitate exploring the expression data.
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http://bioconductor.org/packages/devel/bioc/html/synlet.html synlet Hits Selection for Synthetic Lethal RNAi Screen Data

2015-08-06T17:36:37.333358Z

Select hits from synthetic lethal RNAi screen data. For example, there are two identical celllines except one gene is knocked-down in one cellline. The interest is to find genes that lead to stronger lethal effect when they are knocked-down further by siRNA. Quality control and various visualisation tools are implemented. Four different algorithms could be used to pick up the interesting hits. This package is designed based on 384 wells plates, but may apply to other platforms with proper configuration.
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http://bioconductor.org/packages/devel/bioc/html/NanoStringDiff.html NanoStringDiff Differential Expression Analysis of NanoString nCounter Data

2015-08-06T17:36:37.333358Z

This Package utilizes a generalized linear model(GLM) of the negative binomial family to characterize count data and allows for multi-factor design. NanoStrongDiff incorporate size factors, calculated from positive controls and housekeeping controls, and background level, obtained from negative controls, in the model framework so that all the normalization information provided by NanoString nCounter Analyzer is fully utilized.
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http://bioconductor.org/packages/devel/bioc/html/metaX.html metaX An R package for metabolomic data analysis

2015-08-06T17:36:37.333358Z

The package provides a integrated pipeline for mass spectrometry-based metabolomic data analysis. It includes the stages peak detection, data preprocessing, normalization, missing value imputation, univariate statistical analysis, multivariate statistical analysis such as PCA and PLS-DA, metabolite identification, pathway analysis, power analysis, feature selection and modeling, data quality assessment.
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http://bioconductor.org/packages/devel/bioc/html/eudysbiome.html eudysbiome pseudo-cartesian plot and contingency test on 16S Microbial data

Xiaoyuan Zhou, Christine Nardini — 2015-08-10T12:32:11.913116Z

eudysbiome a package that permits to annotate the differential genera as harmful/harmless based on their ability to contribute to host diseases (as indicated in literature) or as unknown based on their ambiguous genus classification. Further, the package statistically measures the eubiotic (harmless genera increase or harmful genera decrease) or dysbiotic(harmless genera decrease or harmful genera increase) impact of a given treatment or environmental change on the (gut-intestinal, GI) microbiome in comparison to the microbiome of the reference condition.
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http://bioconductor.org/packages/devel/bioc/html/Oscope.html Oscope Oscope - A statistical pipeline for identifying oscillatory genes in unsynchronized single cell RNA-seq

Ning Leng — 2015-07-30T18:18:36.745851Z

Oscope is a statistical pipeline developed to identifying and recovering the base cycle profiles of oscillating genes in an unsynchronized single cell RNA-seq experiment. The Oscope pipeline includes three modules: a sine model module to search for candidate oscillator pairs; a K-medoids clustering module to cluster candidate oscillators into groups; and an extended nearest insertion module to recover the base cycle order for each oscillator group.
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http://bioconductor.org/packages/devel/bioc/html/variancePartition.html variancePartition Quantify and interpret divers of variation in multilevel gene expression experiments

Gabriel E. Hoffman — 2015-08-05T22:25:33.056928Z

Use linear mixed model to quantify variation in gene expression attributable to individual, tissue, time point, or technical variables.
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http://bioconductor.org/packages/devel/bioc/html/destiny.html destiny Creates diffusion maps

2015-08-11T07:48:52.933606Z

Create and plot diffusion maps
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http://bioconductor.org/packages/devel/bioc/html/HilbertCurve.html HilbertCurve Making 2D Hilbert Curve

Zuguang Gu — 2015-08-19T21:41:11.514005Z

Hilbert curve is a type of space-filling curves that fold one dimensional axis into a two dimensional space, but with still keep the locality. This package aims to provide a easy and flexible way to visualize data through Hilbert curve.
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http://bioconductor.org/packages/devel/bioc/html/LedPred.html LedPred Learning from DNA to Predict enhancers

Elodie Darbo, Denis Seyres, Aitor Gonzalez — 2015-07-24T13:44:00.108100Z

This package aims at creating a predictive model of regulatory sequences used to score unknown sequences based on the content of DNA motifs, next-generation sequencing (NGS) peaks and signals and other numerical scores of the sequences using supervised classification. The package contains a workflow based on the support vector machine (SVM) algorithm that maps features to sequences, optimize SVM parameters and feature number and creates a model that can be stored and used to score the regulatory potential of unknown sequences.
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http://bioconductor.org/packages/devel/bioc/html/traseR.html traseR GWAS trait-associated SNP enrichment analyses in genomic intervals

Li Chen, Zhaohui S.Qin — 2015-07-16T19:09:19.535227Z

traseR performs GWAS trait-associated SNP enrichment analyses in genomic intervals using different hypothesis testing approaches, also provides various functionalities to explore and visualize the results.
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http://bioconductor.org/packages/devel/bioc/html/OGSA.html OGSA Outlier Gene Set Analysis

2015-07-16T19:09:19.535227Z

OGSA provides a global estimate of pathway deregulation in cancer subtypes by integrating the estimates of significance for individual pathway members that have been identified by outlier analysis.
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http://bioconductor.org/packages/devel/bioc/html/miRLAB.html miRLAB Dry lab for exploring miRNA-mRNA relationships

Thuc Duy Le, Junpeng Zhang — 2015-08-06T02:05:37.034976Z

Provide tools exploring miRNA-mRNA relationships, including popular miRNA target prediction methods, ensemble methods that integrate individual methods, functions to get data from online resources, functions to validate the results, and functions to conduct enrichment analyses.
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http://bioconductor.org/packages/devel/bioc/html/genotypeeval.html genotypeeval QA/QC of a gVCF or VCF file

Jennifer Tom [aut, cre] — 2015-07-16T19:09:19.535227Z

Takes in a gVCF or VCF and reports metrics to assess quality of calls.
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http://bioconductor.org/packages/devel/bioc/html/ropls.html ropls PCA, PLS(-DA) and OPLS(-DA) for multivariate analysis and feature selection of omics data

2015-08-25T10:15:13.920919Z

Latent variable modeling with Principal Component Analysis (PCA) and Partial Least Squares (PLS) are powerful methods for visualization, regression, classification, and feature selection of omics data where the number of variables exceeds the number of samples and with multicollinearity among variables. Orthogonal Partial Least Squares (OPLS) enables to separately model the variation correlated (predictive) to the factor of interest and the uncorrelated (orthogonal) variation. While performing similarly to PLS, OPLS facilitates interpretation. Successful applications of these chemometrics techniques include spectroscopic data such as Raman spectroscopy, nuclear magnetic resonance (NMR), mass spectrometry (MS) in metabolomics and proteomics, but also transcriptomics data. In addition to scores, loadings and weights plots, the package provides metrics and graphics to determine the optimal number of components (e.g. with the R2 and Q2 coefficients), check the validity of the model by permutation testing, detect outliers, and perform feature selection (e.g. with Variable Importance in Projection or regression coefficients). The package can be accessed via a user interface on the Workflow4Metabolomics.org online resource for computational metabolomics (built upon the Galaxy environment).
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http://bioconductor.org/packages/devel/bioc/html/rCGH.html rCGH Comprehensive Pipeline for Analyzing and Visualizing Agilent and Affymetrix Array-Based CGH Data

2015-08-26T11:49:27.416381Z

A comprehensive pipeline for analyzing and interactively visualizing genomic profiles generated through Agilent and Affymetrix microarrays. As inputs, rCGH supports Agilent dual-color Feature Extraction files (.txt), from 44 to 400K, and Affymetrix SNP6.0 and cytoScan probeset.txt, cychp.txt, and cnchp.txt files, exported from ChAS or Affymetrix Power Tools. This package takes over all the steps required for a genomic profile analysis, from reading the files to the segmentation and genes annotations, and provides several visualization functions (static or interactive) which facilitate profiles interpretation. Input files can be in compressed format, e.g. .bz2 or .gz.
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http://bioconductor.org/packages/devel/bioc/html/TimerQuant.html TimerQuant Timer Quantification

Joseph Barry — 2015-08-19T02:55:25.507337Z

Supplementary Data package for tandem timer methods paper by Barry et al. (2015) including TimerQuant shiny applications.
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http://bioconductor.org/packages/devel/bioc/html/DeMAND.html DeMAND DeMAND

2015-07-23T22:19:32.708803Z

DEMAND predicts Drug MoA by interrogating a cell context specific regulatory network with a small number (N >= 6) of compound-induced gene expression signatures, to elucidate specific proteins whose interactions in the network is dysregulated by the compound.
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http://bioconductor.org/packages/devel/bioc/html/rnaseqcomp.html rnaseqcomp Benchmark for RNA-seq Quantification Pipelines

Mingxiang Teng and Rafael A. Irizarry — 2015-08-05T20:36:19.307667Z

Several quantitative and visualized benchmarks for RNA-seq quantification pipelines. Two-replicate quantifications for genes, transcripts, junctions or exons by each pipeline with nessasery meta information should be organizd into numeric matrix in order to proceed the evaluation.
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http://bioconductor.org/packages/devel/bioc/html/INSPEcT.html INSPEcT Analysis of 4sU-seq and RNA-seq time-course data

Stefano de Pretis — 2015-06-30T12:11:51.299829Z

INSPEcT (INference of Synthesis, Processing and dEgradation rates in Time-Course experiments) analyses 4sU-seq and RNA-seq time-course data in order to evaluate synthesis, processing and degradation rates and asses via modeling the rates that determines changes in mature mRNA levels.
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http://bioconductor.org/packages/devel/bioc/html/Prize.html Prize Prize: an R package for prioritization estimation based on analytic hierarchy process

2015-06-25T21:35:13.350012Z

The high throughput studies often produce large amounts of numerous genes and proteins of interest. While it is difficult to study and validate all of them. Analytic Hierarchy Process (AHP) offers a novel approach to narrowing down long lists of candidates by prioritizing them based on how well they meet the research goal. AHP is a mathematical technique for organizing and analyzing complex decisions where multiple criteria are involved. The technique structures problems into a hierarchy of elements, and helps to specify numerical weights representing the relative importance of each element. Numerical weight or priority derived from each element allows users to find alternatives that best suit their goal and their understanding of the problem.
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http://bioconductor.org/packages/devel/bioc/html/XBSeq.html XBSeq Test for differential expression for RNA-seq data

Yuanhang Liu — 2015-08-10T19:17:41.780518Z

We developed a novel algorithm, XBSeq, where a statistical model was established based on the assumption that observed signals are the convolution of true expression signals and sequencing noises. The mapped reads in non-exonic regions are considered as sequencing noises, which follows a Poisson distribution. Given measureable observed and noise signals from RNA-seq data, true expression signals, assuming governed by the negative binomial distribution, can be delineated and thus the accurate detection of differential expressed genes.
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http://bioconductor.org/packages/devel/bioc/html/CNVPanelizer.html CNVPanelizer Reliable CNV detection in targeted sequencing applications

Cristiano Oliveira and Thomas Wolf with contributions from Volker and Nicole — 2015-06-25T21:35:13.350012Z

A method that allows for the use of a collection of non-matched normal tissue samples. Our approach uses a non-parametric bootstrap subsampling of the available reference samples to estimate the distribution of read counts from targeted sequencing. As inspired by random forest, this is combined with a procedure that subsamples the amplicons associated with each of the targeted genes. The obtained information allows us to reliably classify the copy number aberrations on the gene level.
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http://bioconductor.org/packages/devel/bioc/html/fCI.html fCI f-divergence Cutoff Index

Shaojun Tang — 2015-06-17T08:48:14.162400Z

(f-divergence Cutoff Index), is to find DEGs in the transcriptomic & proteomic data, and identify DEGs by computing the difference between the distribution of fold-changes for the control-control and remaining (non-differential) case-control gene expression ratio data. fCI provides several advantages compared to existing methods.
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http://bioconductor.org/packages/devel/bioc/html/IONiseR.html IONiseR Quality Assessment Tools for Oxford Nanopore MinION data

Mike Smith [aut, cre] — 2015-08-25T11:35:06.719379Z

IONiseR provides tools for the quality assessment of Oxford Nanopore MinION data. It extracts summary statistics from a set of fast5 files and can be used either before or after base calling. In addition to standard summaries of the read-types produced, it provides a number of plots for visualising metrics relative to experiment run time or spatially over the surface of a flowcell.
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http://bioconductor.org/packages/devel/bioc/html/erma.html erma epigenomic road map adventures

2015-08-28T17:33:22.637398Z

Software and data to support epigenomic road map adventures.
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http://bioconductor.org/packages/devel/bioc/html/PGA.html PGA An package for identification of novel peptides by customized database derived from RNA-Seq

Shaohang Xu, Bo Wen — 2015-08-08T01:35:09.559541Z

This package provides functions for construction of customized protein databases based on RNA-Seq data, database searching, post-processing and report generation. This kind of customized protein database includes both the reference database (such as Refseq or ENSEMBL) and the novel peptide sequences form RNA-Seq data.
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http://bioconductor.org/packages/devel/bioc/html/mirIntegrator.html mirIntegrator Integrating microRNA expression into signaling pathways for pathway analysis

2015-06-09T21:33:49.274999Z

Tools for augmenting signaling pathways to perform pathway analysis of microRNA and mRNA expression levels.
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http://bioconductor.org/packages/devel/bioc/html/SEPA.html SEPA SEPA

Zhicheng Ji, Hongkai Ji — 2015-07-11T22:45:02.654026Z

Given single-cell RNA-seq data and true experiment time of cells or pseudo-time cell ordering, SEPA provides convenient functions for users to assign genes into different gene expression patterns such as constant, monotone increasing and increasing then decreasing. SEPA then performs GO enrichment analysis to analysis the functional roles of genes with same or similar patterns.
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http://bioconductor.org/packages/devel/bioc/html/hierGWAS.html hierGWAS Asessing statistical significance in predictive GWA studies

Laura Buzdugan — 2015-08-05T14:09:43.245507Z

Testing individual SNPs, as well as arbitrarily large groups of SNPs in GWA studies, using a joint model of all SNPs. The method controls the FWER, and provides an automatic, data-driven refinement of the SNP clusters to smaller groups or single markers.
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http://bioconductor.org/packages/devel/bioc/html/mtbls2.html mtbls2 Böttcher et al. (2004) Comparative LC/MS-based profiling of silver nitrate-treated Arabidopsis thaliana leaves of wild-type and cyp79B2 cyp79B3 double knockout plants

2015-06-08T18:03:39.681916Z

Indole-3-acetaldoxime (IAOx) represents an early intermediate of the biosynthesis of a variety of indolic secondary metabolites including the phytoanticipin indol-3-ylmethyl glucosinolate and the phytoalexin camalexin (3-thiazol-2'-yl-indole). Arabidopsis thaliana cyp79B2 cyp79B3 double knockout plants are completely impaired in the conversion of tryptophan to indole-3-acetaldoxime and do not accumulate IAOx-derived metabolites any longer. Consequently, comparative analysis of wild-type and cyp79B2 cyp79B3 plant lines has the potential to explore the complete range of IAOx-derived indolic secondary metabolites.
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http://bioconductor.org/packages/devel/bioc/html/caOmicsV.html caOmicsV Visualization of multi-dimentional cancer genomics data

Henry Zhang — 2015-06-01T17:31:57.698564Z

caOmicsV package provides methods to visualize multi-dimentional cancer genomics data including of patient information, gene expressions, DNA methylations, DNA copy number variations, and SNP/mutations in matrix layout or network layout.
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http://bioconductor.org/packages/devel/bioc/html/RareVariantVis.html RareVariantVis Visualization of rare variants in whole genome sequencing data

Tomasz Stokowy — 2015-07-11T10:01:22.735531Z

Genomic variants can be analyzed and visualized using many tools. Unfortunately, number of tools for global interrogation of variants is limited. Package RareVariantVis aims to present genomic variants (especially rare ones) in a global, per chromosome way. Visualization is performed in two ways - standard that outputs png figures and interactive that uses JavaScript d3 package. Interactive visualization allows to analyze trio/family data, for example in search for causative variants in rare Mendelian diseases.
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http://bioconductor.org/packages/devel/bioc/html/ELMER.html ELMER Inferring Regulatory Element Landscapes and Transcription Factor Networks Using Cancer Methylomes

2015-08-17T18:04:16.357556Z

ELMER is designed to use DNA methylation and gene expression from a large number of samples to infere regulatory element landscape and transcription factor network in primary tissue.
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http://bioconductor.org/packages/devel/bioc/html/OperaMate.html OperaMate An R package of Data Importing, Processing and Analysis for Opera High Content Screening System

Chenglin Liu — 2015-05-15T18:39:36.307027Z

OperaMate is a flexible R package dealing with the data generated by PerkinElmer's Opera High Content Screening System. The functions include the data importing, normalization and quality control, hit detection and function analysis.
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http://bioconductor.org/packages/devel/bioc/html/acde.html acde Artificial Components Detection of Differentially Expressed Genes

Juan Pablo Acosta, Liliana Lopez-Kleine — 2015-06-02T03:49:16.635776Z

This package provides a multivariate inferential analysis method for detecting differentially expressed genes in gene expression data. It uses artificial components, close to the data's principal components but with an exact interpretation in terms of differential genetic expression, to identify differentially expressed genes while controlling the false discovery rate (FDR). The methods on this package are described in the vignette or in the article 'Multivariate Method for Inferential Identification of Differentially Expressed Genes in Gene Expression Experiments' by J. P. Acosta, L. Lopez-Kleine and S. Restrepo (2015, pending publication).
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http://bioconductor.org/packages/devel/bioc/html/CausalR.html CausalR Causal Reasoning on Biological Networks

2015-05-01T17:24:10.510417Z

Causal Reasoning algorithms for biological networks, including predictions, scoring, p-value calculation and ranking
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http://bioconductor.org/packages/devel/bioc/html/RTCGAToolbox.html RTCGAToolbox A new tool for exporting TCGA Firehose data

Mehmet Kemal Samur — 2015-05-29T02:20:03.890411Z

Managing data from large scale projects such as The Cancer Genome Atlas (TCGA) for further analysis is an important and time consuming step for research projects. Several efforts, such as Firehose project, make TCGA pre-processed data publicly available via web services and data portals but it requires managing, downloading and preparing the data for following steps. We developed an open source and extensible R based data client for Firehose pre-processed data and demonstrated its use with sample case studies. Results showed that RTCGAToolbox could improve data management for researchers who are interested with TCGA data. In addition, it can be integrated with other analysis pipelines for following data analysis.
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http://bioconductor.org/packages/devel/bioc/html/SummarizedExperiment.html SummarizedExperiment SummarizedExperiment container

Martin Morgan, Valerie Obenchain, Jim Hester, Herv\'e Pag\`es — 2015-08-28T19:14:05.705003Z

The SummarizedExperiment container contains one or more assays, each represented by a matrix-like object of numeric or other mode. The rows typically represent genomic ranges of interest and the columns represent samples.
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http://bioconductor.org/packages/devel/bioc/html/BEclear.html BEclear Correct for batch effects in DNA methylation data

Markus Merl, Ruslan Akulenko — 2015-04-16T20:02:44.156675Z

Provides some functions to detect and correct for batch effects in DNA methylation data. The core function "BEclear" is based on latent factor models and can also be used to predict missing values in any other matrix containing real numbers.
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http://bioconductor.org/packages/devel/bioc/html/EMDomics.html EMDomics Earth Mover's Distance for Differential Analysis of Genomics Data

2015-08-16T20:33:47.660781Z

The EMDomics algorithm is used to perform a supervised multi-class analysis to measure the magnitude and statistical significance of observed continuous genomics data between groups. Usually the data will be gene expression values from array-based or sequence-based experiments, but data from other types of experiments can also be analyzed (e.g. copy number variation). Traditional methods like Significance Analysis of Microarrays (SAM) and Linear Models for Microarray Data (LIMMA) use significance tests based on summary statistics (mean and standard deviation) of the distributions. This approach lacks power to identify expression differences between groups that show high levels of intra-group heterogeneity. The Earth Mover's Distance (EMD) algorithm instead computes the "work" needed to transform one distribution into another, thus providing a metric of the overall difference in shape between two distributions. Permutation of sample labels is used to generate q-values for the observed EMD scores. This package also incorporates the Komolgorov-Smirnov (K-S) test and the Cramer von Mises test (CVM), which are both common distribution comparison tests.
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http://bioconductor.org/packages/devel/bioc/html/edge.html edge Extraction of Differential Gene Expression

2015-04-16T20:13:59.915362Z

The edge package implements methods for carrying out differential expression analyses of genome-wide gene expression studies. Significance testing using the optimal discovery procedure and generalized likelihood ratio tests (equivalent to F-tests and t-tests) are implemented for general study designs. Special functions are available to facilitate the analysis of common study designs, including time course experiments. Other packages such as snm, sva, and qvalue are integrated in edge to provide a wide range of tools for gene expression analysis.
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http://bioconductor.org/packages/devel/bioc/html/pwOmics.html pwOmics Pathway-based data integration of omics data

2015-08-24T07:15:17.224061Z

pwOmics performs pathway-based level-specific data comparison of matching omics data sets based on pre-analysed user-specified lists of differential genes/transcripts and proteins. A separate downstream analysis of proteomic data including pathway identification and enrichment analysis, transcription factor identification and target gene identification is opposed to the upstream analysis starting with gene or transcript information as basis for identification of upstream transcription factors and regulators. The cross-platform comparative analysis allows for comprehensive analysis of single time point experiments and time-series experiments by providing static and dynamic analysis tools for data integration.
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http://bioconductor.org/packages/devel/bioc/html/similaRpeak.html similaRpeak similaRpeak: Metrics to estimate a level of similarity between two ChIP-Seq profiles

2015-06-03T02:34:54.224912Z

This package calculates metrics which assign a level of similarity between ChIP-Seq profiles.
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http://bioconductor.org/packages/devel/bioc/html/msa.html msa Multiple Sequence Alignment

Enrico Bonatesta, Christoph Horejs-Kainrath, Ulrich Bodenhofer — 2015-06-12T08:49:45.231094Z

This package provides a unified R/Bioconductor interface to the multiple sequence alignment algorithms ClustalW, ClustalOmega, and Muscle. All three algorithms are integrated in the package, therefore, they do not depend on any external software tools and are available for all major platforms. The multiple sequence alignment algorithms are complemented by a function for pretty-printing multiple sequence alignments using the LaTeX package TeXshade.
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http://bioconductor.org/packages/devel/bioc/html/RnBeads.html RnBeads RnBeads

2015-08-28T12:57:23.022820Z

RnBeads facilitates comprehensive analysis of various types of DNA methylation data at the genome scale.
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http://bioconductor.org/packages/devel/bioc/html/flowVS.html flowVS Variance stabilization in flow cytometry (and microarrays)

Ariful Azad — 2015-04-16T20:02:44.156675Z

Per-channel variance stabilization from a collection of flow cytometry samples by Bertlett test for homogeneity of variances. The approach is applicable to microarrays data as well.
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http://bioconductor.org/packages/devel/bioc/html/ENCODExplorer.html ENCODExplorer A compilation of ENCODE metadata

2015-06-04T17:43:06.356211Z

This package allows user to quickly access ENCODE project files metadata and give access to helper functions to query the ENCODE rest api, download ENCODE datasets and save the database in SQLite format.
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http://bioconductor.org/packages/devel/bioc/html/CAnD.html CAnD Perform Chromosomal Ancestry Differences (CAnD) Analyses

Caitlin McHugh — 2015-04-21T01:28:21.106941Z

Functions to perform the non-parametric and parametric CAnD tests on a set of ancestry proportions. For a particular ancestral subpopulation, a user will supply the estimated ancestry proportion for each sample, and each chromosome or chromosomal segment of interest. A p-value for each chromosome as well as an overall CAnD p-value will be returned for each test. Plotting functions are also available.
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http://bioconductor.org/packages/devel/bioc/html/diffHic.html diffHic Differential analyis of Hi-C data

2015-08-18T03:50:40.744348Z

Detects differential interactions across biological conditions in a Hi-C experiment. Methods are provided for read alignment and data pre-processing into interaction counts. Statistical analysis is based on edgeR and supports normalization and filtering. Several visualization options are also available.
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http://bioconductor.org/packages/devel/bioc/html/FlowRepositoryR.html FlowRepositoryR FlowRepository R Interface

Josef Spidlen [aut, cre] — 2015-04-22T16:33:04.352275Z

This package provides an interface to search and download data and annotations from FlowRepository (flowrepository.org). It uses the FlowRepository programming interface to communicate with a FlowRepository server.
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http://bioconductor.org/packages/devel/bioc/html/R3CPET.html R3CPET 3CPET: Finding Co-factor Complexes in Chia-PET experiment using a Hierarchical Dirichlet Process

M. N. Djekidel, Yang Chen et al. — 2015-04-21T08:20:08.635422Z

The package provides a method to infer the set of proteins that are more probably to work together to maintain chormatin interaction given a ChIA-PET experiment results.
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http://bioconductor.org/packages/devel/bioc/html/pandaR.html pandaR PANDA algorithm

2015-07-14T20:42:00.170286Z

Runs PANDA, an algorithm for discovering novel network structure by combining information from multiple complimentary data sources.
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http://bioconductor.org/packages/devel/bioc/html/ENmix.html ENmix Data preprocessing and quality control for Illumina HumanMethylation450 BeadChip

2015-08-08T14:05:55.884879Z

Illumina HumanMethylation450 BeadChip array measurements have intrinsic levels of background noise that degrade methylation measurement. The ENmix package provides an efficient data pre-processing tool designed to reduce background noise and improve signal for DNA methylation estimation. The package utilizes a novel model-based background correction method, ENmix, that significantly improve accuracy and reproducibility of methylation measures. The data structure used by the ENmix package is compatible with several other related R packages, such as minfi, wateRmelon and ChAMP, providing straightforward integration of ENmix-corrected datasets for subsequent data analysis. The software is designed to support large scale data analysis, and provides multi-processor parallel computing wrappers for commonly used data preprocessing methods, including BMIQ probe design type bias correction and ComBat batch effect correction. In addition ENmix package has selectable complementary functions for efficient data visualization (such as data distribution plotting), quality control (identification and filtering of low quality data points, samples, probes, and outliers, along with imputation of missing values), inter-array normalization (3 different quantile normalizations), identification of probes with multimodal distributions due to SNPs and other factors, and exploration of data variance structure using principal component regression analysis plots. Together these provide a set of flexible and transparent tools for preprocessing of EWAS data in a computationally-efficient and user-friendly package.
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http://bioconductor.org/packages/devel/bioc/html/soGGi.html soGGi Visualise ChIP-seq, MNase-seq and motif occurrence as aggregate plots Summarised Over Grouped Genomic Intervals

Gopuraja Dharmalingam, Tom Carroll — 2015-06-22T07:16:39.384773Z

The soGGi package provides a toolset to create genomic interval aggregate/summary plots of signal or motif occurence from BAM and bigWig files as well as PWM, rlelist, GRanges and GAlignments Bioconductor objects. soGGi allows for normalisation, transformation and arithmetic operation on and between summary plot objects as well as grouping and subsetting of plots by GRanges objects and user supplied metadata. Plots are created using the GGplot2 libary to allow user defined manipulation of the returned plot object. Coupled together, soGGi features a broad set of methods to visualise genomics data in the context of groups of genomic intervals such as genes, superenhancers and transcription factor binding events.
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http://bioconductor.org/packages/devel/bioc/html/MethTargetedNGS.html MethTargetedNGS Perform Methylation Analysis on Next Generation Sequencing Data

2015-04-16T20:02:44.156675Z

Perform step by step methylation analysis of Next Generation Sequencing data.
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http://bioconductor.org/packages/devel/bioc/html/conumee.html conumee Enhanced copy-number variation analysis using Illumina 450k methylation arrays

Volker Hovestadt, Marc Zapatka — 2015-04-16T20:02:44.156675Z

This package contains a set of processing and plotting methods for performing copy-number variation (CNV) analysis using Illumina 450k methylation arrays.
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http://bioconductor.org/packages/devel/bioc/html/RCyjs.html RCyjs Display and manipulate graphs in Cytoscape.js

Paul Shannon — 2015-08-23T22:30:37.414567Z

Interactvive viewing and exploration of graphs, connecting R to Cytoscape.js
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http://bioconductor.org/packages/devel/bioc/html/TPP.html TPP Analyze thermal proteome profiling (TPP) experiments

Dorothee Childs, Holger Franken, Mikhail Savitski and Wolfgang Huber — 2015-08-25T13:53:32.230641Z

Analyze thermal proteome profiling (TPP) experiments with varying temperatures (TR) or compound concentrations (CCR).
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http://bioconductor.org/packages/devel/bioc/html/NanoStringQCPro.html NanoStringQCPro Quality metrics and data processing methods for NanoString mRNA gene expression data

2015-07-29T20:46:06.912614Z

NanoStringQCPro provides a set of quality metrics that can be used to assess the quality of NanoString mRNA gene expression data -- i.e. to identify outlier probes and outlier samples. It also provides different background subtraction and normalization approaches for this data. It outputs suggestions for flagging samples/probes and an easily sharable html quality control output.
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http://bioconductor.org/packages/devel/bioc/html/GoogleGenomics.html GoogleGenomics R Client for Google Genomics API

2015-07-15T18:07:02.228630Z

Provides an R package to interact with the Google Genomics API.
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http://bioconductor.org/packages/devel/bioc/html/CopywriteR.html CopywriteR Copy number information from targeted sequencing using off-target reads

Thomas Kuilman — 2015-07-13T22:28:17.907668Z

CopywriteR extracts DNA copy number information from targeted sequencing by utiizing off-target reads. It allows for extracting uniformly distributed copy number information, can be used without reference, and can be applied to sequencing data obtained from various techniques including chromatin immunoprecipitation and target enrichment on small gene panels. Thereby, CopywriteR constitutes a widely applicable alternative to available copy number detection tools.
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http://bioconductor.org/packages/devel/bioc/html/cogena.html cogena co-expressed gene-set enrichment analysis

2015-08-19T09:45:18.667786Z

To discovery smaller scale, but highly correlated cellular events that may be of great biological relevance, co-expressed gene set enrichment analysis, cogena, aims to cluster gene expression profiles (coExp) for gene co-expression analysis and then implement enrichment analysis for each clusters (clEnrich) based on hyper-geometric test. The results can be visulised by heatmapCluster and heatmapPEI. Based on different gene sets used, cogena can be used as a tool for pathway analysis, GO enrichment analysis, drug repositioning and so on.
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http://bioconductor.org/packages/devel/bioc/html/BrowserVizDemo.html BrowserVizDemo BrowserVizDemo: How to subclass BrowserViz

Paul Shannon — 2015-04-16T20:02:44.156675Z

A BrowserViz subclassing example, xy plotting in the browser using d3
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http://bioconductor.org/packages/devel/bioc/html/SVM2CRM.html SVM2CRM SVM2CRM: support vector machine for cis-regulatory elements detections

2015-04-16T20:02:44.156675Z

Detection of cis-regulatory elements using svm implemented in LiblineaR.
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http://bioconductor.org/packages/devel/bioc/html/RUVcorr.html RUVcorr Removal of unwanted variation for gene-gene correlations and related analysis

Saskia Freytag — 2015-06-02T03:10:17.307191Z

RUVcorr allows to apply global removal of unwanted variation (ridged version of RUV) to real and simulated gene expression data.
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http://bioconductor.org/packages/devel/bioc/html/OmicsMarkeR.html OmicsMarkeR Classification and Feature Selection for 'Omics' Datasets

2015-08-24T14:30:33.624635Z

Tools for classification and feature selection for 'omics' level datasets. It is a tool to provide multiple multivariate classification and feature selection techniques complete with multiple stability metrics and aggregation techniques. It is primarily designed for analysis of metabolomics datasets but potentially extendable to proteomics and transcriptomics applications.
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http://bioconductor.org/packages/devel/bioc/html/mogsa.html mogsa Multiple omics data integration and gene set analysis

Chen Meng — 2015-07-26T15:44:59.495818Z

This package provide a method for doing gene set analysis based on multiple omics data.
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http://bioconductor.org/packages/devel/bioc/html/FISHalyseR.html FISHalyseR FISHalyseR a package for automated FISH quantification

2015-04-16T20:02:44.156675Z

FISHalyseR provides functionality to process and analyse digital cell culture images, in particular to quantify FISH probes within nuclei. Furthermore, it extract the spatial location of each nucleus as well as each probe enabling spatial co-localisation analysis.
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http://bioconductor.org/packages/devel/bioc/html/DMRcaller.html DMRcaller Differentially Methylated Regions caller

2015-04-23T08:31:34.116043Z

Uses Bisulfite sequencing data in two conditions and identifies differentially methylated regions between the conditions in CG and non-CG context. The input is the CX report files produced by Bismark and the output is a list of DMRs stored as GRanges objects.
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http://bioconductor.org/packages/devel/bioc/html/regioneR.html regioneR Association analysis of genomic regions based on permutation tests

2015-08-24T11:08:15.934146Z

regioneR offers a statistical framework based on customizable permutation tests to assess the association between genomic region sets and other genomic features.
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http://bioconductor.org/packages/devel/bioc/html/pmm.html pmm Parallel Mixed Model

Anna Drewek — 2015-04-16T20:02:44.156675Z

The Parallel Mixed Model (PMM) approach is suitable for hit selection and cross-comparison of RNAi screens generated in experiments that are performed in parallel under several conditions. For example, we could think of the measurements or readouts from cells under RNAi knock-down, which are infected with several pathogens or which are grown from different cell lines.
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http://bioconductor.org/packages/devel/bioc/html/ComplexHeatmap.html ComplexHeatmap Making Complex Heatmaps

Zuguang Gu — 2015-08-25T19:56:39.773419Z

Complex heatmaps are efficient to visualize associations between different sources of data sets and reveal potential structures. Here the ComplexHeatmap package provides a highly flexible way to arrange multiple heatmaps and supports self-defined annotation graphics.
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http://bioconductor.org/packages/devel/bioc/html/RBM.html RBM RBM: a R package for microarray and RNA-Seq data analysis

Dongmei Li and Chin-Yuan Liang — 2015-06-07T20:19:54.616631Z

Use A Resampling-Based Empirical Bayes Approach to Assess Differential Expression in Two-Color Microarrays and RNA-Seq data sets.
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http://bioconductor.org/packages/devel/bioc/html/podkat.html podkat Position-Dependent Kernel Association Test

Ulrich Bodenhofer — 2015-06-16T06:35:08.934852Z

This package provides an association test that is capable of dealing with very rare and even private variants. This is accomplished by a kernel-based approach that takes the positions of the variants into account. The test can be used for pre-processed matrix data, but also directly for variant data stored in VCF files. Association testing can be performed whole-genome, whole-exome, or restricted to pre-defined regions of interest. The test is complemented by tools for analyzing and visualizing the results.
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http://bioconductor.org/packages/devel/bioc/html/LowMACA.html LowMACA LowMACA - Low frequency Mutation Analysis via Consensus Alignment

Stefano de Pretis , Giorgio Melloni — 2015-08-28T15:06:12.840972Z

The LowMACA package is a simple suite of tools to investigate and analyze the mutation profile of several proteins or pfam domains via consensus alignment. You can conduct an hypothesis driven exploratory analysis using our package simply providing a set of genes or pfam domains of your interest.
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http://bioconductor.org/packages/devel/bioc/html/rcellminer.html rcellminer rcellminer: Molecular Profiles and Drug Response for the NCI-60 Cell Lines

Augustin Luna, Vinodh Rajapakse, Fabricio Sousa — 2015-05-28T20:29:52.632952Z

The NCI-60 cancer cell line panel has been used over the course of several decades as an anti-cancer drug screen. This panel was developed as part of the Developmental Therapeutics Program (DTP, http://dtp.nci.nih.gov/) of the U.S. National Cancer Institute (NCI). Thousands of compounds have been tested on the NCI-60, which have been extensively characterized by many platforms for gene and protein expression, copy number, mutation, and others (Reinhold, et al., 2012). The purpose of the CellMiner project (http://discover.nci.nih.gov/cellminer) has been to integrate data from multiple platforms used to analyze the NCI-60 and to provide a powerful suite of tools for exploration of NCI-60 data.
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http://bioconductor.org/packages/devel/bioc/html/gtrellis.html gtrellis Genome Level Trellis Layout

Zuguang Gu — 2015-08-22T11:49:45.205395Z

Genome level Trellis graph visualizes genomic data conditioned by genomic categories (e.g. chromosomes). For each genomic category, multiple dimensional data which are represented as tracks describe different features from different aspects. This package provides high flexibility to arrange genomic categories and add self-defined graphics in the plot.
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http://bioconductor.org/packages/devel/bioc/html/ensembldb.html ensembldb Utilities to create and use an Ensembl based annotation database

2015-07-16T06:34:50.187646Z

The package provides functions to create and use transcript centric annotation databases/packages. The annotation for the databases are directly fetched from Ensembl using their Perl API. The functionality and data is similar to that of the TxDb packages from the GenomicFeatures package, but, in addition to retrieve all gene/transcript models and annotations from the database, the ensembldb package provides also a filter framework allowing to retrieve annotations for specific entries like genes encoded on a chromosome region or transcript models of lincRNA genes.
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http://bioconductor.org/packages/devel/bioc/html/TIN.html TIN Transcriptome instability analysis

Bjarne Johannessen, Anita Sveen and Rolf I. Skotheim — 2015-04-16T20:02:44.156675Z

The TIN package implements a set of tools for transcriptome instability analysis based on exon expression profiles. Deviating exon usage is studied in the context of splicing factors to analyse to what degree transcriptome instability is correlated to splicing factor expression. In the transcriptome instability correlation analysis, the data is compared to both random permutations of alternative splicing scores and expression of random gene sets.
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http://bioconductor.org/packages/devel/bioc/html/InPAS.html InPAS Identification of Novel alternative PolyAdenylation Sites (PAS)

Jianhong Ou, Sung Mi Park, Michael R. Green and Lihua Julie Zhu — 2015-08-13T21:24:25.778162Z

Alternative polyadenylation (APA) is one of the important post-transcriptional regulation mechanisms which occurs in most human genes. InPAS facilitates the discovery of novel APA sites from RNAseq data. It leverages cleanUpdTSeq to fine tune identified APA sites.
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http://bioconductor.org/packages/devel/bioc/html/GENESIS.html GENESIS GENetic EStimation and Inference in Structured samples (GENESIS): Statistical methods for analyzing genetic data from samples with population structure and/or relatedness

Matthew P. Conomos and Timothy Thornton — 2015-04-16T20:02:44.156675Z

The GENESIS package provides methodology for estimating, inferring, and accounting for population and pedigree structure in genetic analyses. The current implementation provides functions to perform PC-AiR (Conomos et al., 2015): a Principal Components Analysis with genome-wide SNP genotype data for robust population structure inference in samples with related individuals (known or cryptic).
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http://bioconductor.org/packages/devel/bioc/html/bamsignals.html bamsignals Extract read count signals from bam files

Alessandro Mammana [aut, cre], Johannes Helmuth [aut] — 2015-06-15T13:52:32.428428Z

This package allows to efficiently obtain count vectors from indexed bam files. It counts the number of reads in given genomic ranges and it computes reads profiles and coverage profiles. It also handles paired-end data.
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http://bioconductor.org/packages/devel/bioc/html/SIMAT.html SIMAT GC-SIM-MS data processing and alaysis tool

2015-06-25T19:21:28.775550Z

This package provides a pipeline for analysis of GC-MS data acquired in selected ion monitoring (SIM) mode. The tool also provides a guidance in choosing appropriate fragments for the targets of interest by using an optimization algorithm. This is done by considering overlapping peaks from a provided library by the user.
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http://bioconductor.org/packages/devel/bioc/html/RNAprobR.html RNAprobR An R package for analysis of massive parallel sequencing based RNA structure probing data

2015-08-03T16:00:12.816515Z

This package facilitates analysis of Next Generation Sequencing data for which positional information with a single nucleotide resolution is a key. It allows for applying different types of relevant normalizations, data visualization and export in a table or UCSC compatible bedgraph file.
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http://bioconductor.org/packages/devel/bioc/html/netbenchmark.html netbenchmark Benchmarking of several gene network inference methods

2015-08-10T09:20:10.732412Z

This package implements a benchmarking of several gene network inference algorithms from gene expression data.
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http://bioconductor.org/packages/devel/bioc/html/MatrixRider.html MatrixRider Obtain total affinity and occupancies for binding site matrices on a given sequence

Elena Grassi — 2015-04-16T20:02:44.156675Z

Calculates a single number for a whole sequence that reflects the propensity of a DNA binding protein to interact with it. The DNA binding protein has to be described with a PFM matrix, for example gotten from Jaspar.
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http://bioconductor.org/packages/devel/bioc/html/LEA.html LEA LEA: an R package for Landscape and Ecological Association Studies

2015-04-16T20:02:44.156675Z

LEA is an R package dedicated to landscape genomics and ecological association tests. LEA can run analyses of population structure and genome scans for local adaptation. It includes statistical methods for estimating ancestry coefficients from large genotypic matrices and evaluating the number of ancestral populations (snmf, pca); and identifying genetic polymorphisms that exhibit high correlation with some environmental gradient or with the variables used as proxies for ecological pressures (lfmm), and controlling the false discovery rate. LEA is mainly based on optimized C programs that can scale with the dimension of very large data sets.
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http://bioconductor.org/packages/devel/bioc/html/immunoClust.html immunoClust immunoClust - Automated Pipeline for Population Detection in Flow Cytometry

2015-04-16T20:02:44.156675Z

Model based clustering and meta-clustering of Flow Cytometry Data
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http://bioconductor.org/packages/devel/bioc/html/diggit.html diggit Inference of Genetic Variants Driving Cellular Phenotypes

2015-04-30T17:26:20.206056Z

Inference of Genetic Variants Driving Cellullar Phenotypes by the DIGGIT algorithm
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http://bioconductor.org/packages/devel/bioc/html/canceR.html canceR A Graphical User Interface for accessing and modeling the Cancer Genomics Data of MSKCC.

Karim Mezhoud. Nuclear Safety Department. Nuclear Science Center of Tunisia. — 2015-07-15T22:59:56.434055Z

The package is user friendly interface based on the cgdsr and other modeling packages to explore, compare, and analyse all available Cancer Data (Clinical data, Gene Mutation, Gene Methylation, Gene Expression, Protein Phosphorylation, Copy Number Alteration) hosted by the Computational Biology Center at Memorial-Sloan-Kettering Cancer Center (MSKCC).
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http://bioconductor.org/packages/devel/bioc/html/muscle.html muscle Multiple Sequence Alignment with MUSCLE

Algorithm by Robert C. Edgar. R port by Alex T. Kalinka. — 2015-04-16T20:02:44.156675Z

MUSCLE performs multiple sequence alignments of nucleotide or amino acid sequences.
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